Today, when I tried to run an eDiscovery Export (ClickOnce application), an error appeared stating “Your administrator has blocked this application because it potentially poses a security risk to your computer” and “Your security settings do not allow this application to be installed on your computer”.

This message seems to be due to strict or incorrect settings in Internet Options of Internet Explorer. However, in 9 out of 10 cases, only a few registry settings need to be changed.
Solution for Your administrator has blocked this application because it potentially poses a security risk to your computer
You will most likely solve the Application Install – Security Warning by adjusting 3 registry values. By default, .NET Framework settings block the installation of all ClickOnce applications. Which is a good thing in the first place, because running any application without knowing could lead to serious security issues. However, in this case, we want to allow the application to run. In the following how-to, you learn how to fix Your administrator has blocked this application because it potentially poses a security risk to your computer:
How to fix Your administrator has blocked this application because it potentially poses a security risk to your computer
Step 1. Open Registry Editor
Click Start , type Registry and open Registry Editor. If you are asked if the application is allowed to make changes, click Yes.
If in doubt about required permissions, run Registry Editor as administrator

Navigate to Computer\HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\.NETFramework\Security\TrustManager\PromptingLevel
For all register entries, the Data is probably set to Disabled.
Step 3. Set Internet, LocalIntranet and TrustedSites to Enabled

Double click and adjust the Data to Enabled for these entries: Internet, LocalIntranet, TrustedSites
Step 4. Re-run the application

Try to run the application again. You do not have to restart the browser. You should now be prompted to Install (or to Not Install) the application
Step 5. Install the application
Click Install to install and run the application.
Step 6. Uninstall the application if needed
If you ever want to remove the application, go to Programs and Features / Apps & Features. From there you can uninstall.
Additional information
The error “Your administrator has blocked this application” may occur in your browser, such as Internet Explorer, Microsoft Edge, Google Chrome or Mozilla Firefox. But the window may also popup when you double-click the application file from Windows File Explorer. In either case, changing the registry keys may solve your problem.
The error has also been reported with the installation of Windows 10 IoT Core Dashboard, BIM 360 Glue Desktop, Fidelity Active Trader Pro and Deltek Ajera.
Worked like a champ. I screen clipped the registry so I could restore it after. Even the software company couldn’t help.
Amazing, worked thank you for installing a medical practice management software (Gensolve) which downloads files from their server.
I did have to set ‘Enabled’ to ‘UntrusteSites’ temporarily for the application to install.
Tried many other things with no success, much appreciated.
Thanks!
Excellent! I was able to run Fidelity Active TraderPro. Thank you for this!
P.S. after running the application I restored the registry settings to disabled. The application still ran after doing this, just in case anyone was curious.
Thank you vey much
Thank you so much, this has solved our problem
Very happy. This solved our problem with our application on a Windows 10 computer. THANK YOU VERY MUCH !!!
You’re very welcome :)
Great help. I had this issue on both IE and Chromium Edge and couldn’t figure out why.
Excellent tips! Helped me install Fidelity Active Trader Pro